Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

Shijia Zhu; Naoto Kubota; Yujin Hoshida

doi:10.1016/j.tig.2021.01.007

Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

Shijia Zhu, Naoto Kubota, Yujin Hoshida

Research output: Contribution to journal › Short survey › peer-review

Abstract

Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.

Original language	English (US)
Pages (from-to)	403-404
Number of pages	2
Journal	Trends in Genetics
Volume	37
Issue number	5
DOIs	https://doi.org/10.1016/j.tig.2021.01.007
State	Published - May 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021

Keywords

gene regulatory network
human induced pluripotent stem cell
organogenesis

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10.1016/j.tig.2021.01.007

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title = "Transcriptome-Guided Design of Physiological Multilineage Liver Organoids",

abstract = "Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.",

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author = "Shijia Zhu and Naoto Kubota and Yujin Hoshida",

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year = "2021",

month = may,

doi = "10.1016/j.tig.2021.01.007",

language = "English (US)",

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T1 - Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

AU - Zhu, Shijia

AU - Kubota, Naoto

AU - Hoshida, Yujin

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N2 - Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.

AB - Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.

KW - gene regulatory network

KW - human induced pluripotent stem cell

KW - organogenesis

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Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

Abstract

Bibliographical note

Keywords

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