Training DNA Perceptrons via Fractional Coding

Xingyi Liu, Keshab K. Parhi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


This paper describes a novel approach to synthesize molecular reactions to train a perceptron, i.e., a single-layered neural network, with sigmoidal activation function. The approach is based on fractional coding where a variable is represented by two molecules. The synergy between fractional coding in molecular computing and stochastic logic implementations in electronic computing is key to translating known stochastic logic circuits to molecular computing. In prior work, a DNA perceptron with bipolar inputs and unipolar output was proposed for inference. The focus of this paper is on synthesis of molecular reactions for training of the DNA perceptron. A new molecular scaler that performs multiplication by a factor greater than 1 is proposed based on fractional coding. The training of the perceptron proposed in this paper is based on a modified backpropagation equation as the exact equation cannot be easily mapped to molecular reactions using fractional coding.

Original languageEnglish (US)
Title of host publicationConference Record - 53rd Asilomar Conference on Circuits, Systems and Computers, ACSSC 2019
EditorsMichael B. Matthews
PublisherIEEE Computer Society
Number of pages5
ISBN (Electronic)9781728143002
StatePublished - Nov 2019
Event53rd Asilomar Conference on Circuits, Systems and Computers, ACSSC 2019 - Pacific Grove, United States
Duration: Nov 3 2019Nov 6 2019

Publication series

NameConference Record - Asilomar Conference on Signals, Systems and Computers
ISSN (Print)1058-6393


Conference53rd Asilomar Conference on Circuits, Systems and Computers, ACSSC 2019
Country/TerritoryUnited States
CityPacific Grove

Bibliographical note

Publisher Copyright:
© 2019 IEEE.


  • Backpropagation
  • DNA Computing
  • Fractional Coding
  • Molecular Computing
  • Molecular Scaler
  • Per-ceptron


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