TRAIL: A molecule with multiple receptors and control mechanisms

Thomas S. Griffith; David H. Lynch

doi:10.1016/S0952-7915(98)80224-0

TRAIL: A molecule with multiple receptors and control mechanisms

Thomas S. Griffith
, David H. Lynch

Urology

Research output: Contribution to journal › Article › peer-review

444 Scopus citations

Abstract

Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.

Original language	English (US)
Pages (from-to)	559-563
Number of pages	5
Journal	Current Opinion in Immunology
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/S0952-7915(98)80224-0
State	Published - Oct 1998

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10.1016/S0952-7915(98)80224-0

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title = "TRAIL: A molecule with multiple receptors and control mechanisms",

abstract = "Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.",

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year = "1998",

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AU - Lynch, David H.

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AB - Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.

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DO - 10.1016/S0952-7915(98)80224-0

M3 - Article

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JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

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ER -

TRAIL: A molecule with multiple receptors and control mechanisms

Abstract

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