TRAIL: A molecule with multiple receptors and control mechanisms

Thomas S. Griffith, David H. Lynch

Research output: Contribution to journalArticlepeer-review

430 Scopus citations


Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.

Original languageEnglish (US)
Pages (from-to)559-563
Number of pages5
JournalCurrent Opinion in Immunology
Issue number5
StatePublished - Oct 1998

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