Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model

Michael B.A. Oldstone, Peter J. Southern

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or β cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalJournal of Neuroimmunology
Volume46
Issue number1-2
DOIs
StatePublished - Jul 1993

Bibliographical note

Funding Information:
This is PublicationN umber7798-NP from the Department of NeuropharmacologTyh, e Scripps Research Institute,L a Jolla, CA. This work was supported in part by USPHS grants NS-12428 and AI-09484.D ale McFarlin was a friend,s cientificc ollabora-tor and associate( of MBAO) for over the last two decades.

Keywords

  • Central nervous system
  • Cytotoxic T lymphocytes
  • Trafficking

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