Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model

Michael B.A. Oldstone; Peter J. Southern

doi:10.1016/0165-5728(93)90230-V

Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model

Michael B.A. Oldstone, Peter J. Southern

Microbiology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or β cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS.

Original language	English (US)
Pages (from-to)	25-31
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	46
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-5728(93)90230-V
State	Published - Jul 1993

Bibliographical note

Funding Information:
This is PublicationN umber7798-NP from the Department of NeuropharmacologTyh, e Scripps Research Institute,L a Jolla, CA. This work was supported in part by USPHS grants NS-12428 and AI-09484.D ale McFarlin was a friend,s cientificc ollabora-tor and associate( of MBAO) for over the last two decades.

Keywords

Central nervous system
Cytotoxic T lymphocytes
Trafficking

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10.1016/0165-5728(93)90230-V

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title = "Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model",

abstract = "We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or β cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS.",

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year = "1993",

month = jul,

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AU - Oldstone, Michael B.A.

AU - Southern, Peter J.

N1 - Funding Information: This is PublicationN umber7798-NP from the Department of NeuropharmacologTyh, e Scripps Research Institute,L a Jolla, CA. This work was supported in part by USPHS grants NS-12428 and AI-09484.D ale McFarlin was a friend,s cientificc ollabora-tor and associate( of MBAO) for over the last two decades.

PY - 1993/7

Y1 - 1993/7

N2 - We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or β cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS.

AB - We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or β cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS.

KW - Central nervous system

KW - Cytotoxic T lymphocytes

KW - Trafficking

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Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model

Abstract

Bibliographical note

Keywords

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