Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning

Keyphrases

• Protein Solubility 100%
• Deep mutational Scanning 100%
• Yeast Surface Display 50%
• Fitness Landscape 50%
• Levoglucosan Kinase 50%
• High-throughput 25%
• Protein Function 25%
• Missense mutation 25%
• Rare mutation 25%
• Biological Basis 25%
• Evolutionary Distance 25%
• Active Sites 25%
• Catalytic Activity 25%
• Marginally Stable 25%
• Biotechnological Applications 25%
• Crystalline Structure 25%
• Hybrid Classifier 25%
• Evolutionary Conservation 25%
• Active Enzyme 25%
• Competing Effect 25%
• Classification Model 25%
• Contact number 25%
• Display Screen 25%
• Twin-arginine Translocation 25%
• Pathway Selection 25%
• TEM-1 β-lactamase 25%
• Global Protein Stability 25%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Wild Type 33%
• Phosphotransferase 33%
• Kinase 33%
• Active Site 16%
• Enzymatic Activity 16%
• Genetic Conservation 16%
• Missense Mutation 16%
• Protein Stability 16%
• Beta-Lactamase 16%
• Arginine 16%