Tracking microdomain dynamics in cell membranes

Charles A. Day, Anne K. Kenworthy

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations


Studies of the diffusion of proteins and lipids in the plasma membrane of cells have long pointed to the presence of membrane domains. A major challenge in the field of membrane biology has been to characterize the various cellular structures and mechanisms that impede free diffusion in cell membranes and determine the consequences that membrane compartmentalization has on cellular biology. In this review, we will provide a brief summary of the classes of domains that have been characterized to date, focusing on recent efforts to identify the properties of lipid rafts in cells through measurements of protein and lipid diffusion.

Original languageEnglish (US)
Pages (from-to)245-253
Number of pages9
JournalBiochimica et Biophysica Acta - Biomembranes
Issue number1
StatePublished - Jan 2009
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by R01 GM073846 from the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIGMS or the NIH.


  • Fluorescence correlation spectroscopy
  • Fluorescence recovery after photobleaching
  • Lateral diffusion
  • Lipid raft
  • Membrane microdomain
  • Single particle tracking


Dive into the research topics of 'Tracking microdomain dynamics in cell membranes'. Together they form a unique fingerprint.

Cite this