Tracking microdomain dynamics in cell membranes

Charles A. Day, Anne K. Kenworthy

Research output: Contribution to journalReview article

75 Scopus citations

Abstract

Studies of the diffusion of proteins and lipids in the plasma membrane of cells have long pointed to the presence of membrane domains. A major challenge in the field of membrane biology has been to characterize the various cellular structures and mechanisms that impede free diffusion in cell membranes and determine the consequences that membrane compartmentalization has on cellular biology. In this review, we will provide a brief summary of the classes of domains that have been characterized to date, focusing on recent efforts to identify the properties of lipid rafts in cells through measurements of protein and lipid diffusion.

Original languageEnglish (US)
Pages (from-to)245-253
Number of pages9
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1788
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Fluorescence correlation spectroscopy
  • Fluorescence recovery after photobleaching
  • Lateral diffusion
  • Lipid raft
  • Membrane microdomain
  • Single particle tracking

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