TY - JOUR
T1 - Traceless solid-phase synthesis of N-substituted 3,5-bis(substituted-idene) piperidin-4-one derivatives
AU - Liu, Zhang
AU - Medina-Franco, Jose L.
AU - Houghten, Richard A.
AU - Giulianotti, Marc A.
N1 - Funding Information:
This work was supported by the State of Florida, Executive Office of the Governor’s Office of Tourism, Trade and Economic Development .
PY - 2010
Y1 - 2010
N2 - A series of N-substituted 3,5-bis(substituted-idene)piperidin-4-ones have been prepared using solidphase organic synthesis. The synthesis starts with a Michael addition with piperidin-4-one serving as the donor and REM resin as the acceptor. Various aldehydes were then utilized through a Knoevenagel condensation to afford the 3,5-bis(substituted-idene)piperidin-4-ones on the solid support. The final products were removed from the support and a second diversity position was introduced through a Hofmann elimination using different alkyl bromides.
AB - A series of N-substituted 3,5-bis(substituted-idene)piperidin-4-ones have been prepared using solidphase organic synthesis. The synthesis starts with a Michael addition with piperidin-4-one serving as the donor and REM resin as the acceptor. Various aldehydes were then utilized through a Knoevenagel condensation to afford the 3,5-bis(substituted-idene)piperidin-4-ones on the solid support. The final products were removed from the support and a second diversity position was introduced through a Hofmann elimination using different alkyl bromides.
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U2 - 10.1016/j.tetlet.2010.07.072
DO - 10.1016/j.tetlet.2010.07.072
M3 - Article
AN - SCOPUS:78549287084
SN - 0040-4039
VL - 51
SP - 5003
EP - 5004
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 38
ER -