Toxicologic evaluation of bacterial synthesized cellulose in endothelial cells and animals

Seong Il Jeong, Seung Eun Lee, Hana Yang, Young Ho Jin, Cheung Seog Park, Yong Seek Park

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Compared to plant cellulose, bacterial cellulose synthesized by Gluconacetobacter xylinus has features such as high crystallinity, tensile strength and water absorption capacity; biocompatibility; resistance to degradation and low solubility that may be advantageous for engineered tissue. However, little information is available concerning the potential toxicity of bacterial cellulose-based biomaterials. The present study investigated the toxicity of bacterial cellulose nanofibers in vitro in human umbilical vein endothelial cells (HUVECs) using viability and flow cytometric assays and in vivo using C57/Bl6 mice. The absence of toxicity in vitro and in vivo supports the view that bacterial cellulose may be amenable for use as a tissue engineering biomaterial.

Original languageEnglish (US)
Pages (from-to)373-380
Number of pages8
JournalMolecular and Cellular Toxicology
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2010

Keywords

  • Bacterial cellulose
  • Biocompatibility
  • Endothelial cells
  • Gluconacetobacter xylinus
  • Tissue engineering

Fingerprint

Dive into the research topics of 'Toxicologic evaluation of bacterial synthesized cellulose in endothelial cells and animals'. Together they form a unique fingerprint.

Cite this