Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: A brief discussion of concepts

Roman Ashauer, Annika Agatz, Carlo Albert, Virginie Ducrot, Nika Galic, Jan Hendriks, Tjalling Jager, Andreas Kretschmann, Isabel O'Connor, Mascha Nadine Rubach, Anna Maija Nyman, Walter Schmitt, Julita Stadnicka, Paul J. van den Brink, Thomas G. Preuss

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined.

Original languageEnglish (US)
Pages (from-to)2519-2524
Number of pages6
JournalEnvironmental Toxicology and Chemistry
Volume30
Issue number11
DOIs
StatePublished - Nov 2011

Keywords

  • Adverse outcome pathway
  • Dose-response
  • Dynamic energy budget
  • Mechanistic effect model
  • Toxicity

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