Toxic nephropathy

R. N. Foley, B. J. Barrett, P. S. Parfrey

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations
Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalAnnals of the Royal College of Physicians and Surgeons of Canada
Issue number1
StatePublished - 1992

Bibliographical note

Funding Information:
Most drugs and biologically active compounds are transported to their site of action viaa the circulation . The two kidneys comprising about 0 .4 per cent of the body weight receive about 25 per cent of the resting minute output of the heart and thus are exposed quickly to peak concentrations of chemicals, even those which are transiently circulating . The kidney has a high oxygen consumption and is susceptible to agents producing cellular anoxia . A vascular rete mirabile serves as a countercurrent mechanism resulting in hypertonicity of the interstitium of the renal papillae so that local concentrations of specific compounds as well as of osmotically active solutes may exist to a degree not found in * From the Department of Medicine, Georgetown University School of Medicine and the Renal and Electrolyte Division, Georgetown University Hospital, Washington, D . C. This study was supported in part by the John A . Hartford Foundation, Inc . and the Georgetown University Kidney Research Fund, Washington, D . C . Manuscript re-ccived March 5 . 1964 .

Copyright 2004 Elsevier B.V., All rights reserved.

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