Towards advanced chemical and biological nanosensors - An overview

Chanda Ranjit Yonzon, Douglas A. Stuart, Xiaoyu Zhang, Adam D. McFarland, Christy L. Haynes, Richard P. Van Duyne

Research output: Contribution to journalArticlepeer-review

308 Scopus citations


This paper reviews recent developments in the design and application of two types of optical nanosensor, those based on: (1) localized surface plasmon resonance (LSPR) spectroscopy and (2) surface-enhanced Raman scattering (SERS). The performance of these sensors is discussed in the context of biological and chemical sensing. The first section addresses the LSPR sensors. Arrays of nanotriangles were evaluated and characterized using realistic protein/ligand interactions. Isolated, single nanoparticles were used for chemosensing and performed comparably to the nanoparticle array sensors. In particular, we highlight the effect of nanoparticle morphology on sensing response. The second section details the use of SERS sensors using metal film over nanosphere (MFON) surfaces. The high SERS enhancements and long-term stability of MFONs were exploited in order to develop SERS-based sensors for two important target molecules: a Bacillus anthracis biomarker and glucose in a serum protein mixture.

Original languageEnglish (US)
Pages (from-to)438-448
Number of pages11
Issue number3
StatePublished - Sep 15 2005


  • Localized surface plasmon resonance
  • Metal film over nanosphere
  • Nanosensor
  • Nanosphere lithography
  • Surface-enhanced Raman scattering

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