Toward salivary-urinary chronosensitivity testing: Chronomes of OVX1, M-CSF and CA130

F. Xu, Y. Yu, R. C. Bast, Germaine G Cornelissen-Guillaume, S. Fujii, M. Takagi, T. O'Brien, F. Halberg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Several rhythmic components were previously mapped for salivary and/or urinary CA125 and CA130. On the back-ground of such reference standards, OVX1 and M-CSF were assayed on 242 urine samples and 160 saliva samples provided by a 71-year-old patient with a Mullerian/ovarian adenocarcinoma. Serum OVX1 correlates with serum CA125 (P=0.002) when circulating CA125 concentrations decreased (from 122 to 14 U/ml), the urinary excretion rate of OVX1 decreased (P=0.005), whereas the urinary excretion rate of CA125 increased (P<0.001). Salivary OVX1 and urinary M-CSF show ultradian variations (with a frequency of one cycle in 14-17 hours), which could be utilized to guide treatment timing targetted first to optimize treatment efficacy and as a second consideration to minimize treatment toxicity.

Original languageEnglish (US)
Pages (from-to)407-412
Number of pages6
JournalIn Vivo
Issue number4
StatePublished - 1995

Bibliographical note

Copyright 2021 Elsevier B.V., All rights reserved.


  • Blood
  • CA125
  • CA130
  • Chronosensitivity
  • M-CSF
  • OVX1
  • Ovarian cancer
  • Saliva
  • Urine treatment timing


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