Two studies examined the effectiveness of an innovative program, Mathematics, Engineering Science Achievement (MESA), designed to prepare high school minority students for math-based fields. The program is noteworthy because it incorporates recommendations of educators and policymakers for improving the quality of math/science education and decreasing the underrepresentation of minorities in these fields. Study 1 showed that MESA seniors completed more math/science courses and showed higher academic performance than similar minority students. However, their verbal and mathematics performance was below seniors nationwide planning math-based college majors. Study 2 revealed that the majority of former MESA students were pursuing a math-based major at the university level and showed satisfactory postsecondary progress. Features contributing to program effectiveness and areas requiring additional action are explored.