Abstract
Child and adolescent psychiatric neuroimaging research typically lags behind similar advances in adult disorders. While the pediatric depression imaging literature is less developed, a recent surge in interest has created the need for a synthetic review of this work. Major findings from pediatric volumetric and functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and resting state functional connectivity studies converge to implicate a corticolimbic network of key areas that work together to mediate the task of emotion regulation. Imaging the brain of children and adolescents with unipolar depression began with volumetric studies of isolated brain regions that served to identify key prefrontal, cingulate and limbic nodes of depression-related circuitry elucidated from more recent advances in DTI and functional connectivity imaging. Systematic review of these studies preliminarily suggests developmental differences between findings in youth and adults, including prodromal neurobiological features, along with some continuity across development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 307-328 |
| Number of pages | 22 |
| Journal | Brain Imaging and Behavior |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2011 |
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Keywords
- Adolescents
- MRI brain imaging
- Major depressive disorder
- Neuroimaging
- Pediatric depression
- fMRI
Cite this
Toward dysfunctional connectivity : A review of neuroimaging findings in pediatric major depressive disorder. / Hulvershorn, Leslie A.; Cullen, Kathryn R; Anand, Amit.
In: Brain Imaging and Behavior, Vol. 5, No. 4, 01.12.2011, p. 307-328.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Toward dysfunctional connectivity
T2 - A review of neuroimaging findings in pediatric major depressive disorder
AU - Hulvershorn, Leslie A.
AU - Cullen, Kathryn R
AU - Anand, Amit
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Child and adolescent psychiatric neuroimaging research typically lags behind similar advances in adult disorders. While the pediatric depression imaging literature is less developed, a recent surge in interest has created the need for a synthetic review of this work. Major findings from pediatric volumetric and functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and resting state functional connectivity studies converge to implicate a corticolimbic network of key areas that work together to mediate the task of emotion regulation. Imaging the brain of children and adolescents with unipolar depression began with volumetric studies of isolated brain regions that served to identify key prefrontal, cingulate and limbic nodes of depression-related circuitry elucidated from more recent advances in DTI and functional connectivity imaging. Systematic review of these studies preliminarily suggests developmental differences between findings in youth and adults, including prodromal neurobiological features, along with some continuity across development.
AB - Child and adolescent psychiatric neuroimaging research typically lags behind similar advances in adult disorders. While the pediatric depression imaging literature is less developed, a recent surge in interest has created the need for a synthetic review of this work. Major findings from pediatric volumetric and functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and resting state functional connectivity studies converge to implicate a corticolimbic network of key areas that work together to mediate the task of emotion regulation. Imaging the brain of children and adolescents with unipolar depression began with volumetric studies of isolated brain regions that served to identify key prefrontal, cingulate and limbic nodes of depression-related circuitry elucidated from more recent advances in DTI and functional connectivity imaging. Systematic review of these studies preliminarily suggests developmental differences between findings in youth and adults, including prodromal neurobiological features, along with some continuity across development.
KW - Adolescents
KW - MRI brain imaging
KW - Major depressive disorder
KW - Neuroimaging
KW - Pediatric depression
KW - fMRI
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U2 - 10.1007/s11682-011-9134-3
DO - 10.1007/s11682-011-9134-3
M3 - Review article
VL - 5
SP - 307
EP - 328
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
IS - 4
ER -