Virtually every crucial economic and social function depends on the secure, reliable operation of energy, telecommunications, transportation, financial, and other infrastructures. The nature of electricity demand is undergoing a profound shift in industrialized nations across the globe. From a strategic R&D viewpoint, agility and robustness/survivability of large-scale dynamic networks that face new and unanticipated operating conditions will be presented. A major challenge is posed by the lack of a unified mathematical framework with robust tools for modeling, simulation, control and optimization of time-critical operations in complex multicomponent and multiscaled networks. New tools and techniques are being developed to enable large national infrastructures to function in ways that are self-stabilizing, self-optimizing, and self-healing. This presentation will focus on a strategic vision extending to a decade, or longer, that would enable more secure and robust systems operation, security monitoring and efficient energy markets.