Total synthesis of the potent antitumor, bis-tetrahydrofuranyl annonaceous acetogenins (+)-asimicin and (+)-bullatacin

Thomas R. Hoye, Lushi Tan

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Convergent syntheses of the title compounds involve: a bis-THF-subunit preparation via Sharpless' double asymmetric dihydroxylation and subsequent asymmetric epoxidation; preparation of the C(4)-hydroxybutenolide-containing subunit using a Stille butenolide synthesis; Pdo-mediated coupling of these vinyl iodide and alkyne subunits; and selective Wilkinson reduction of the resulting enyne.

Original languageEnglish (US)
Pages (from-to)1981-1984
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number12
DOIs
StatePublished - Mar 20 1995

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