Total synthesis of (ent)-korupensamine D

Thomas R. Hoye, Minzhang Chen

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


The first total synthesis of the enantiomer of the natural product, korupensamine D (16R), is described. The key steps include a highly efficient preparation of the enantiomerically pure primary amine 4 via the ring opening of aziridine 2 with an arylcuprate reagent and the development of a one-pot selective functionalization of a hindered secondary amine in the presence of phenolic hydroxyl groups (i.e. 8 to 9).

Original languageEnglish (US)
Pages (from-to)3099-3100
Number of pages2
JournalTetrahedron Letters
Issue number18
StatePublished - Apr 29 1996

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