Abstract
A total synthesis of (-)-callipeltoside A (1) has been achieved. The core macrocycle was made via a dual macrolactonization/pyran hemiketal formation reaction, developed to circumvent issues related to the reversible nature of acylketene formation from β-keto lactone substrates. Initial approaches to the core of the natural product that revolved around ring-closing metathesis (RCM) and relay ring-closing metathesis (RRCM) reactions are also described.
Original language | English (US) |
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Pages (from-to) | 7052-7060 |
Number of pages | 9 |
Journal | Journal of Organic Chemistry |
Volume | 75 |
Issue number | 21 |
DOIs | |
State | Published - Nov 5 2010 |