Abstract
By utilizing an l-serine-derived bicyclic lactone as an advanced chiral building block, a short synthetic route to the cytotoxic marine natural product jaspine B has been developed. Targeting structure-activity relationship investigations, the synthetic route has also been utilized for the synthesis and cytotoxicity evaluation of strategically modified jaspine B analogues. In addition, a previously reported synthesis of the title natural product from our research has been reinvestigated to clarify the sterochemical assignment.
| Original language | English (US) |
|---|---|
| Article number | ss-2016-m0623-op |
| Pages (from-to) | 2088-2100 |
| Number of pages | 13 |
| Journal | Synthesis (Germany) |
| Volume | 49 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 3 2017 |
Bibliographical note
Publisher Copyright:© Georg Thieme Verlag Stuttgart · New York-Synthesis 2017.
Keywords
- cytotoxic
- drug development
- jaspine B
- stereochemistry
- structure-activity relationships
