Total Pancreactectomy with Islet Autotransplant Failure: Now What?

Ty B. Dunn; Varvara A. Kirchner; K. Louise Berry; Melena D. Bellin; David E.R. Sutherland; Timothy L. Pruett

doi:10.1007/s40472-015-0057-6

Total Pancreactectomy with Islet Autotransplant Failure: Now What?

Ty B. Dunn, Varvara A. Kirchner, K. Louise Berry, Melena D. Bellin, David E.R. Sutherland, Timothy L. Pruett

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Total pancreatectomy with islet cell autotransplant (TPIAT) is a definitive therapeutic approach to pain management for patients with chronic pancreatitis that is non-responsive to maximum medical management. Total pancreatectomy (TP) results in brittle diabetes unless islet cell autotransplant (IAT) is concomitantly performed. Even with IAT, about 30 % of patients will require long-term basal-bolus insulin therapy due to significant endocrine insufficiency. The focus of this review is on the utility of whole organ pancreas transplantation toward improving quality of life, and decreasing the risk of mortality and overall cost of care for the subset of patients who experience endocrine and exocrine deficiency after pancreatic resection.

Original language	English (US)
Pages (from-to)	144-148
Number of pages	5
Journal	Current Transplantation Reports
Volume	2
Issue number	2
DOIs	https://doi.org/10.1007/s40472-015-0057-6
State	Published - Jun 1 2015

Bibliographical note

Publisher Copyright:
© 2015, Springer International Publishing AG.

Keywords

Brittle diabetes
Cost
Pancreas transplant
Quality of life
Survival
Total pancreatectomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s40472-015-0057-6

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title = "Total Pancreactectomy with Islet Autotransplant Failure: Now What?",

abstract = "Total pancreatectomy with islet cell autotransplant (TPIAT) is a definitive therapeutic approach to pain management for patients with chronic pancreatitis that is non-responsive to maximum medical management. Total pancreatectomy (TP) results in brittle diabetes unless islet cell autotransplant (IAT) is concomitantly performed. Even with IAT, about 30 % of patients will require long-term basal-bolus insulin therapy due to significant endocrine insufficiency. The focus of this review is on the utility of whole organ pancreas transplantation toward improving quality of life, and decreasing the risk of mortality and overall cost of care for the subset of patients who experience endocrine and exocrine deficiency after pancreatic resection.",

keywords = "Brittle diabetes, Cost, Pancreas transplant, Quality of life, Survival, Total pancreatectomy",

author = "Dunn, {Ty B.} and Kirchner, {Varvara A.} and Berry, {K. Louise} and Bellin, {Melena D.} and Sutherland, {David E.R.} and Pruett, {Timothy L.}",

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doi = "10.1007/s40472-015-0057-6",

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T2 - Now What?

AU - Dunn, Ty B.

AU - Kirchner, Varvara A.

AU - Berry, K. Louise

AU - Bellin, Melena D.

AU - Sutherland, David E.R.

AU - Pruett, Timothy L.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Total pancreatectomy with islet cell autotransplant (TPIAT) is a definitive therapeutic approach to pain management for patients with chronic pancreatitis that is non-responsive to maximum medical management. Total pancreatectomy (TP) results in brittle diabetes unless islet cell autotransplant (IAT) is concomitantly performed. Even with IAT, about 30 % of patients will require long-term basal-bolus insulin therapy due to significant endocrine insufficiency. The focus of this review is on the utility of whole organ pancreas transplantation toward improving quality of life, and decreasing the risk of mortality and overall cost of care for the subset of patients who experience endocrine and exocrine deficiency after pancreatic resection.

AB - Total pancreatectomy with islet cell autotransplant (TPIAT) is a definitive therapeutic approach to pain management for patients with chronic pancreatitis that is non-responsive to maximum medical management. Total pancreatectomy (TP) results in brittle diabetes unless islet cell autotransplant (IAT) is concomitantly performed. Even with IAT, about 30 % of patients will require long-term basal-bolus insulin therapy due to significant endocrine insufficiency. The focus of this review is on the utility of whole organ pancreas transplantation toward improving quality of life, and decreasing the risk of mortality and overall cost of care for the subset of patients who experience endocrine and exocrine deficiency after pancreatic resection.

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KW - Cost

KW - Pancreas transplant

KW - Quality of life

KW - Survival

KW - Total pancreatectomy

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Total Pancreactectomy with Islet Autotransplant Failure: Now What?

Abstract

Bibliographical note

Keywords

UN SDGs

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