Total lymphoid irradiation and cyclophosphamide conditioning prior to bone marrow transplantation for patients with severe aplastic anemia

N. K.C. Ramsay, T. H. Kim, P. McGlave, A. Goldman, M. E. Nesbit, W. Krivit, W. G. Woods, J. H. Kersey

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

A preparative regimen, consisting of total lymphoid irradiation and cyclophosphamide, was utilized in 40 patients with severe aplastic anemia undergoing allogeneic marrow transplantation. This regimen was successful in decreasing rejection in these previously transfused patients, as only one patient rejected the marrow graft. Twenty-nine of the 40 transplanted patients are surviving from 1.5 to 59 mo, with a median follow-up of 24 mo. The actuarial survival rate for these heavily transfused patients with aplastic anemia is 72% at 2 yr. This preparative regimen is extremely effective in decreasing rejection following transplantation for severe aplastic anemia. Future efforts in this area must be aimed at the elimination of graft-versus-host disease and control of fatal infections.

Original languageEnglish (US)
Pages (from-to)622-626
Number of pages5
JournalUnknown Journal
Volume62
Issue number3
DOIs
StatePublished - 1983

Fingerprint Dive into the research topics of 'Total lymphoid irradiation and cyclophosphamide conditioning prior to bone marrow transplantation for patients with severe aplastic anemia'. Together they form a unique fingerprint.

Cite this