Total dietary fat and omega-3 fatty acids have modest effects on urinary sex hormones in postmenopausal women

Lindsay R. Young, Susan K. Raatz, William Thomas, Bruce B Redmon, Mindy S Kurzer

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Total fat and omega-3 fatty acids in the diet may affect breast cancer risk by altering estrogen metabolism. The purpose of this study was to elucidate the effects of differing total fat and omega-3 fatty acid content of diets on a panel of urinary estrogens and metabolites. Findings. A controlled, cross-over feeding trial was conducted in postmenopausal women using three test diets: high fat diet (HF; 40% energy from fat), low fat diet (LF; 20% of energy from fat) and low fat, high omega-3 diet (LFn3; 23% energy from fat; 3% omega-3 fatty acids) for 8 week periods. Urinary hormone concentrations for 16 women were compared among diets using a linear mixed model, and within diet comparisons were made using paired t-tests. Urinary excretion of estrone was greater after the LF and LFn3 compared to the HF (P = 0.004). Estrone excretion was increased from baseline within the LF only (P = 0.02). Total estrone + estradiol + estriol increased from baseline with LF (P = 0.02) and was greater than the other two diets at 8 weeks (P = 0.03). There were no effects on estrogen metabolites, including the 2-hydroxy estrone:16 α-hydroxy estrone ratio. Conclusions: The results of this study indicate that urinary sex hormone metabolism was modestly altered in postmenopausal women by a low fat dietary intervention.

Original languageEnglish (US)
Article number36
JournalNutrition and Metabolism
Volume10
Issue number1
DOIs
StatePublished - May 1 2013

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Dietary Fats
Omega-3 Fatty Acids
Gonadal Steroid Hormones
Estrone
Diet
Fats
Estrogens
Estriol
Fat-Restricted Diet
High Fat Diet
Cross-Over Studies
Estradiol
Linear Models
Hormones
Breast Neoplasms

Keywords

  • Dietary fat
  • Low fat diet
  • Omega-3 fatty acids
  • Postmenopausal women
  • Urinary estrogens

Cite this

Total dietary fat and omega-3 fatty acids have modest effects on urinary sex hormones in postmenopausal women. / Young, Lindsay R.; Raatz, Susan K.; Thomas, William; Redmon, Bruce B; Kurzer, Mindy S.

In: Nutrition and Metabolism, Vol. 10, No. 1, 36, 01.05.2013.

Research output: Contribution to journalArticle

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