Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.
Bibliographical noteFunding Information:
We thank B Vogelstein for the parental and securin-/- HCT116 cells lines. This work was funded by NIH grant CA099033 (D.J.C.). J.F.G.A was partly supported by MEC-Spain DGI (FYK) and L.A.D.M. by CONACyT.
- Topo II
- Topoisomerase II