Topoisomerase II checkpoints: Universal mechanisms that regulate mitosis

Duncan J. Clarke, Amit C. Vas, Catherine A. Andrews, Laura A. Díaz-Martínez, Juan F. Giménez-Abián

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.

Original languageEnglish (US)
Pages (from-to)1925-1928
Number of pages4
JournalCell Cycle
Volume5
Issue number17
DOIs
StatePublished - Sep 1 2006

Bibliographical note

Funding Information:
We thank B Vogelstein for the parental and securin-/- HCT116 cells lines. This work was funded by NIH grant CA099033 (D.J.C.). J.F.G.A was partly supported by MEC-Spain DGI (FYK) and L.A.D.M. by CONACyT.

Keywords

  • Anaphase
  • Catenation
  • Checkpoint
  • Decatenation
  • Mad2
  • Pds1
  • Top2
  • Topo II
  • Topoisomerase II

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