Topical Tacrolimus Compared With Oral Tacrolimus for Postoperative Immunosuppression in Primary Keratolimbal Allograft

Tu M. Tran, Tayaba N. Azher, Corey J. Miller, Joshua H. Hou

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The aim of this study was to compare outcomes between topical tacrolimus and oral tacrolimus as the primary calcineurin inhibitor for postoperative immunosuppression after primary keratolimbal allograft (KLAL) transplantation for limbal stem cell deficiency (LSCD). Methods: We performed a retrospective, comparative cohort study at a single tertiary referral center (University of MN) of all patients who underwent primary KLAL between 2014 and 2021. Eyes were grouped into those which received topical tacrolimus as the only calcineurin inhibitor (topical group) and eyes in which patients received oral tacrolimus with or without topical tacrolimus (oral group). Clinical and donor tissue data were obtained and compared between the 2 groups. Results: In total, 27 eyes of 22 patients (median age 42 years, range 20-79 years) were included, of which 18 eyes were in the oral group and 9 eyes were in the topical group. The mean follow-up time was 33.2 ± 22.6 months. The most frequent etiology of LSCD was alkaline burn (33.3%). At 36 months, graft failure occurred in 6 eyes in the oral group (33.3%) and 2 eyes in the topical group (22.1%) (P = 0.57). The failure rate in the oral group was 9.1 per 1000 person-months versus 8.4 per 1000 person-months in the topical group (P = 0.96). The median improvement in BCVA was logMAR 20.975 and logMAR 20.45 for the oral and topical group, respectively (P = 0.50). Conclusions: With careful patient selection, topical tacrolimus may be a viable alternative to oral tacrolimus in KLAL.

Original languageEnglish (US)
Pages (from-to)333-342
Number of pages10
JournalCornea
Volume43
Issue number3
DOIs
StatePublished - Mar 1 2024

Bibliographical note

Publisher Copyright:
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • immunosuppression
  • keratolimbal allograft
  • limbal stem cell deficiency
  • ocular surface reconstruction
  • tacrolimus

PubMed: MeSH publication types

  • Journal Article

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