Abstract
We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 554-555 |
| Number of pages | 2 |
| Journal | Pediatric Dermatology |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 2019 |
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Keywords
- FGFR3
- acanthosis nigricans
- epidermal nevus
- topical sirolimus
PubMed: MeSH publication types
- Journal Article
Cite this
Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans. / Dodds, Melissa; Maguiness, Sheilagh.
In: Pediatric Dermatology, Vol. 36, No. 4, 01.07.2019, p. 554-555.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans
AU - Dodds, Melissa
AU - Maguiness, Sheilagh
PY - 2019/7/1
Y1 - 2019/7/1
N2 - We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.
AB - We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.
KW - FGFR3
KW - acanthosis nigricans
KW - epidermal nevus
KW - topical sirolimus
UR - http://www.scopus.com/inward/record.url?scp=85064476439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064476439&partnerID=8YFLogxK
U2 - 10.1111/pde.13833
DO - 10.1111/pde.13833
M3 - Article
VL - 36
SP - 554
EP - 555
JO - Pediatric Dermatology
JF - Pediatric Dermatology
SN - 0736-8046
IS - 4
ER -