Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans

Melissa Dodds, Sheilagh Maguiness

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.

Original languageEnglish (US)
Pages (from-to)554-555
Number of pages2
JournalPediatric Dermatology
Volume36
Issue number4
DOIs
StatePublished - Jul 1 2019

Keywords

  • FGFR3
  • acanthosis nigricans
  • epidermal nevus
  • topical sirolimus

PubMed: MeSH publication types

  • Journal Article
  • Case Reports

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