Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans

Melissa Dodds; Sheilagh Maguiness

doi:10.1111/pde.13833

Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans

Melissa Dodds, Sheilagh Maguiness

Dermatology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.

Original language	English (US)
Pages (from-to)	554-555
Number of pages	2
Journal	Pediatric Dermatology
Volume	36
Issue number	4
DOIs	https://doi.org/10.1111/pde.13833
State	Published - Jul 1 2019

Keywords

FGFR3
acanthosis nigricans
epidermal nevus
topical sirolimus

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Case Reports

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10.1111/pde.13833

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abstract = "We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.",

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AU - Maguiness, Sheilagh

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N2 - We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.

AB - We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.

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KW - acanthosis nigricans

KW - epidermal nevus

KW - topical sirolimus

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ER -

Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans

Abstract

Keywords

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