Q-Learning is a method of reinforcement learning that employs backwards stagewise estimation to identify sequences of actions that maximize some long-term reward. The method can be applied to sequential multipleassignment randomized trials to develop personalized adaptive treatment strategies (ATSs)-longitudinal practice guidelines highly tailored to time-varying attributes of individual patients. Sometimes, the basis for choosing which ATSs to include in a sequential multiple-assignment randomized trial (or randomized controlled trial) may be inadequate. Nonrandomized data sources may inform the initial design of ATSs, which could later be prospectively validated. In this paper, we illustrate challenges involved in using nonrandomized data for this purpose with a case study from the Center for International Blood and Marrow Transplant Research registry (1995-2007) aimed at 1) determining whether the sequence of therapeutic classes used in graft-versus-host disease prophylaxis and in refractory graft-versus-host disease is associated with improved survival and 2) identifying donor and patient factors with which to guide individualized immunosuppressant selections over time. We discuss how to communicate the potential benefit derived from following an ATS at the population and subgroup levels and how to evaluate its robustness to modeling assumptions. This worked example may serve as a model for developing ATSs from registries and cohorts in oncology and other fields requiring sequential treatment decisions.
Bibliographical noteFunding Information:
E.F.K. was supported by the Cole Foundation. E.E.M.M. was supported by the Fonds de recherche du Québec–Santé. We thank the Audiovisual Service of Hôpital Maisonneuve-Rosemont and Helen Crawford of the Fred Hutchinson Cancer Research Center for assistance with figure preparation. Conflict of interest: none declared.
© 2017 The Author(s).
- Adaptive treatment strategies
- Dynamic treatment regimes
- Graft-versus-host disease
- Machine learning
- Personalized medicine
- Registry data