Tolerance in methylphenidate-induced locomotion in prairie dogs (cynomys ludovicianus)

Henry L. Schreiber, W. Gibson Wood, Richard H. Carlson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

After a five-day adaptation period in activity wheels, four prairie dogs were assigned to a methylphenidate group (2.5 mg/kg, s.c.) and four prairie dogs were assigned to a saline group for ten consecutive daily injections. Half-revolutions of locomotor activity were recorded during seven measurement periods taken daily. During the third measurement period, from 1-3 hrs following injection, the methylphenidate group declined in locomotor activity over the first three days of drug administration.

Original languageEnglish (US)
Pages (from-to)111-113
Number of pages3
JournalPsychopharmacologia
Volume46
Issue number1
DOIs
StatePublished - Jan 1 1976

Keywords

  • Methylphenidate
  • Motor activity
  • Prairie dogs
  • Tolerance

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