T/NK large granular lymphocyte leukemia and coexisting monoclonal B-cell lymphocytosis-like proliferations an unrecognized and frequent association

Matthew T. Howard, Nelli Bejanyan, Jaroslaw P. Maciejewski, Eric D. Hsi

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

T-cell large granular lymphocyte leukemia (T-LGLL) is a T-cell lymphoproliferative disorder that has recently been associated with B-cell dyscrasias on a spectrum ranging from dysgammaglobulinemia to lymphoma. To investigate the relationship between clonal B-cell and LGLL lymphoproliferations, we systematically studied lymphocytes in 57 patients with T-LGLL or NK lymphocytosis using flow cytometric methods sensitive to low-level B-cell populations. We identified 16 patients (28%) with abnormal B-cell populations; 9 (16%) of the patients had no known history of a B-cell lymphoproliferative disorder. We characterized these abnormal B-cell populations as monoclonal B-cell lymphocytosis and report a high frequency of monoclonal B-cell lymphocytosis in T/NK LGLL. Our findings suggest that certain pathologic factors may operate in patients with T/NK LGLL to drive low-level clonal B-cell proliferations.

Original languageEnglish (US)
Pages (from-to)936-941
Number of pages6
JournalAmerican journal of clinical pathology
Volume133
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • B-cell dyscrasias
  • Flow cytometry
  • Lymphoproliferations
  • Lymphoproliferative disorders
  • T/NK large granular lymphocyte leukemia

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