Tnf-α effect on oxygen free radical scavenging and generating enzymes in rat liver

A. Theologides, A. M. Ingersoll-Stroubos, F. S. Apple

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The presence of cancer induces metabolic alterations in distant, tumor-free tissues and organs of the host. A remote humoral effect of cancer growing extrahepatically is an increase in the activity of oxidant and a decrease of antioxidant enzymes in the liver of the tumor-bearing animal. We speculated that TNF-α, produced by host cells, the cancer, or both, is responsible for these changes. When human recombinant TNF-α, 100 μg/kg/d i.p. for 5 days, was injected in groups of rats fed ad libitum, starved, or pair-fed, a decrease in the activity of superoxide dismutase and glutathione peroxidase and an increase in xanthine oxidase was observed, particularly with pair-fed controls. It is concluded that TNF-α, directly or indirectly, causes these enzyme alterations in the tumor-free liver of a tumor-bearing host.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalBiochemistry and Molecular Biology International
Volume33
Issue number1
StatePublished - Jan 1 1994

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