TMPRSS2 and COVID-19: Serendipity or opportunity for intervention?

Konrad H. Stopsack, Lorelei A. Mucci, Emmanuel S. Antonarakis, Peter S. Nelson, Philip W. Kantoff

Research output: Contribution to journalArticlepeer-review

Abstract

TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.

Original languageEnglish (US)
Pages (from-to)779-782
Number of pages4
JournalCancer discovery
Volume10
Issue number6
DOIs
StatePublished - Jun 2020
Externally publishedYes

Bibliographical note

Funding Information:
The work of the authors is supported by the Prostate Cancer Foundation, the NIH (P30CA008748, P30CA006973, P30CA015704, P01CA163227, P01CA228696), and the Department of Defense (W81XWH-18-1-0330).

Publisher Copyright:
© 2020 American Association for Cancer Research.

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