Tissue-specific transcriptional regulation has diverged significantly between human and mouse

Duncan T. Odom, Robin D. Dowell, Elizabeth S. Jacobsen, William Gordon, Timothy W. Danford, Kenzie D. MacIsaac, P. Alexander Rolfe, Caitlin M. Conboy, David K. Gifford, Ernest Fraenkel

Research output: Contribution to journalArticlepeer-review

393 Scopus citations

Abstract

We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.

Original languageEnglish (US)
Pages (from-to)730-732
Number of pages3
JournalNature Genetics
Volume39
Issue number6
DOIs
StatePublished - Jun 2007

Bibliographical note

Funding Information:
This work was supported by funding from US National Institutes of Health (grants DK68655 and DK70813 (D.T.O.) and DK076284 (R.D.D.)), Cancer Research UK (D.T.O.) and the Whitaker Foundation (E.F.).

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