Tissue-Engineered Heart Valves

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A tissue-engineered heart valve (TEHV) could serve as an implantable valve replacement that would grow and adapt with the patient. A TEHV consists of a degradable scaffold material and relevant cells, either seeded onto or entrapped within the scaffold during in vitro culture or recruited in vivo upon implantation, which produce their own extracellular matrix components as the scaffold degrades. Because the valve consists of living tissue at or post implantation, it can grow and remodel as a patient ages, making it an especially attractive option for pediatric and young adult patients. Using various scaffolds, cell sources, and fabrication methods, several laboratories have produced TEHVs with suitable geometry and mechanics, which have been shown to allow for cell infiltration and remodeling once implanted. TEHVs implanted in both preclinical and clinical trials have shown promising short-term functionality, but many designs have failed to maintain consistently good performance after several months in vivo due to leaflet thickening or shortening, and in situ remodeling can vary from patient to patient. Future TEHV research will focus on optimization of TEHV composition and geometry for sustained function and growth, standardization of manufacturing and implantation procedures, and continued investigation into in situ remodeling processes.

Original languageEnglish (US)
Title of host publicationHeart Valves
Subtitle of host publicationFrom Design to Clinical Implantation
PublisherSpringer Science+Business Media
Pages357-382
Number of pages26
ISBN (Electronic)9783031255410
ISBN (Print)9783031255403
DOIs
StatePublished - Jan 1 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2013, 2023.

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