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Tissue-engineered cultured periosteum sheet application to treat infrabony defects: Case series and 5-year results

  • Kazuhiro Okuda
  • , Tomoyuki Kawase
  • , Masaki Nagata
  • , Kanoko Yamamiya
  • , Koh Nakata
  • , Larry F. Wolff
  • , Hiromasa Yoshie

Research output: Contribution to journalArticlepeer-review

Abstract

One-year data after autologous grafting of infrabony periodontal defects with human cultured periosteum sheets in combination with platelet-rich plasma and hydroxyapatite granules have shown favorable clinical and radiographic results. A 5-year follow-up evaluation of 22 selected patients indicated that treated infrabony defects remained stable. Radiographically, there was an increase in osseous radiopacity and bone trabeculation suggesting further bone maturation. This novel tissue-engineered periodontal treatment approach has resulted in significant clinical improvement, and defects remained stable after 5 years.

Original languageEnglish (US)
Pages (from-to)281-287
Number of pages7
JournalInternational Journal of Periodontics and Restorative Dentistry
Volume33
Issue number3
DOIs
StatePublished - 2013

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