Tissue culture, protein and collagen synthesis in antibiotic sterilized canine heart valves

C. G.A. Mcgregor; J. F. Bradley; J. O.d. Mcgee; D. J. Wheatley

doi:10.1093/cvr/10.3.389

Tissue culture, protein and collagen synthesis in antibiotic sterilized canine heart valves

C. G.A. Mcgregor, J. F. Bradley, J. O.d. Mcgee, D. J. Wheatley

Research output: Contribution to journal › Review article › peer-review

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Abstract

AUTHORS' SYNOPSIS: Viability of canine heart valve leaflet fibroblasts was assessed after varying periods of sterilization and storage in antibiotic-nutrient solution. Tissue culture and assessment of protein and collagen synthesis showed that tissue obtained undsr optimal conditions rarely retains viability beyond 3 weeks in antibiotic-nutrient solution and is severely impaired after 2 weeks. This casts serious doubts on viability in current clinical homograft valve practice.

Original language	English (US)
Pages (from-to)	389-393
Number of pages	5
Journal	Cardiovascular Research
Volume	10
Issue number	3
DOIs	https://doi.org/10.1093/cvr/10.3.389
State	Published - May 1976
Externally published	Yes

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abstract = "AUTHORS' SYNOPSIS: Viability of canine heart valve leaflet fibroblasts was assessed after varying periods of sterilization and storage in antibiotic-nutrient solution. Tissue culture and assessment of protein and collagen synthesis showed that tissue obtained undsr optimal conditions rarely retains viability beyond 3 weeks in antibiotic-nutrient solution and is severely impaired after 2 weeks. This casts serious doubts on viability in current clinical homograft valve practice.",

author = "Mcgregor, {C. G.A.} and Bradley, {J. F.} and Mcgee, {J. O.d.} and Wheatley, {D. J.}",

year = "1976",

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AU - Mcgregor, C. G.A.

AU - Bradley, J. F.

AU - Mcgee, J. O.d.

AU - Wheatley, D. J.

PY - 1976/5

Y1 - 1976/5

N2 - AUTHORS' SYNOPSIS: Viability of canine heart valve leaflet fibroblasts was assessed after varying periods of sterilization and storage in antibiotic-nutrient solution. Tissue culture and assessment of protein and collagen synthesis showed that tissue obtained undsr optimal conditions rarely retains viability beyond 3 weeks in antibiotic-nutrient solution and is severely impaired after 2 weeks. This casts serious doubts on viability in current clinical homograft valve practice.

AB - AUTHORS' SYNOPSIS: Viability of canine heart valve leaflet fibroblasts was assessed after varying periods of sterilization and storage in antibiotic-nutrient solution. Tissue culture and assessment of protein and collagen synthesis showed that tissue obtained undsr optimal conditions rarely retains viability beyond 3 weeks in antibiotic-nutrient solution and is severely impaired after 2 weeks. This casts serious doubts on viability in current clinical homograft valve practice.

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Tissue culture, protein and collagen synthesis in antibiotic sterilized canine heart valves

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