Tissue culture, protein and collagen synthesis in antibiotic sterilized canine heart valves

C. G.A. Mcgregor, J. F. Bradley, J. O.d. Mcgee, D. J. Wheatley

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

AUTHORS' SYNOPSIS: Viability of canine heart valve leaflet fibroblasts was assessed after varying periods of sterilization and storage in antibiotic-nutrient solution. Tissue culture and assessment of protein and collagen synthesis showed that tissue obtained undsr optimal conditions rarely retains viability beyond 3 weeks in antibiotic-nutrient solution and is severely impaired after 2 weeks. This casts serious doubts on viability in current clinical homograft valve practice.

Original languageEnglish (US)
Pages (from-to)389-393
Number of pages5
JournalCardiovascular Research
Volume10
Issue number3
DOIs
StatePublished - May 1976
Externally publishedYes

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