Tipping the mutation-selection balance: Limited migration increases the frequency of deleterious mutants

Jacob D. Cooper, Claudia Neuhauser, Antony M. Dean, Benjamin Kerr

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Typical mutation-selection models assume well-mixed populations, but dispersal and migration within many natural populations is spatially limited. Such limitations can lead to enhanced variation among locations as different types become clustered in different places. Such clustering weakens competition between unlike types relative to competition between like types; thus, the rate by which a fitter type displaces an inferior competitor can be affected by the spatial scale of movement. In this paper, we use a birth-death model to show that limited migration can affect asexual populations by creating competitive refugia. We use a moment closure approach to show that as population structure is introduced by limiting migration, the equilibrial frequency of deleterious mutants increases. We support and extend the model through stochastic simulation, and we use a spatially explicit cellular automaton approach to corroborate the results. We discuss the implications of these results for standing variation in structured populations and adaptive valley crossing in Wright's "shifting balance" process.

Original languageEnglish (US)
Pages (from-to)123-133
Number of pages11
JournalJournal of Theoretical Biology
Volume380
DOIs
StatePublished - Sep 7 2015

Keywords

  • Adaptive valley crossing
  • Fitness landscape
  • Moment closure
  • Population genetics
  • Spatial structure

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