Objective: To determine the relationship between iron deficiency (or iron-deficient, ID) and neural correlates of recognition memory depending on ID timing (gestation vs. infancy) and infant age at testing (9 vs. 18 months). Study design: Event-related potentials (ERP) were used in a visual recognition memory task (mother vs. stranger face) to compare healthy term infants according to iron status at birth and 9 months. Fetal-neonatal ID was defined as cord serum ferritin < 75 µg/l or zinc protoporphrin/heme ratio > 118 µmol/mol, postnatal ID as ≥ 2 abnormal iron measures at 9 months with normal cord-blood iron status, and iron-sufficient as not ID at birth or 9 months. Recognition of mother faces was measured by negative component (Nc) and late slow wave (LSW). These ERP components reflect attention and memory updating processes, respectively. Results: All groups showed differences in Nc amplitude elicited by mother and stranger faces at 9 months. At 18 months, only postnatal ID and iron-sufficient groups showed condition differences in Nc amplitude. However, the 2 groups were different in the involved brain regions. For LSW, only the 2 ID groups showed condition differences in amplitude at 9 months. At 18 months, condition differences were not observed in any group. Conclusions: This study indicates that the timing of ID in early life (fetal-neonatal vs. postnatal) modulates the impact of ID on recognition memory. Such impact also varies depending on the age of infants at testing (9 vs. 18 months).
|Original language||English (US)|
|Number of pages||10|
|Early online date||Jan 7 2020|
|State||Published - 2022|
Bibliographical noteFunding Information:
This study was supported by grants from the National Institutes of Health (P01HD039386, to BL) and the National Natural Science Foundation of China (no. 81273085, to JS). ERP analyses were conducted during FG’s post-doctoral fellowship at the University of Michigan. We thank the participants and their families and Yaping Shi, Liqin Chen, Zheng Shen, Zhengyan Zhao, Mingyan Li, Chai Ji, Zhiwei Zhu, and other team members for assistance with subject enrollment, data collection, and laboratory analyses.
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
- event-related potentials
- fetal-neonatal iron deficiency
- postnatal iron deficiency
- recognition memory
PubMed: MeSH publication types
- Journal Article