Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of drosophila steroid production

Kim F. Rewitz, Michael B O'Connor

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in Drosophila larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile-adult transition.

Original languageEnglish (US)
Article numberArticle 108
JournalFrontiers in Endocrinology
Volume2
Issue numberDEC
DOIs
StatePublished - Dec 1 2011

Keywords

  • 20-hydroxyecdysone
  • Critical weight
  • Cyp6t3
  • Dhr4
  • Metamorphosis

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