@article{e653d60e792a4efe9587b15e80338648,
title = "Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes",
abstract = "OBJECTIVE To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18.2%). We identified three novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648, hazard ratio [HR] 1.23, P = 3.6 × 10-9), rs77142250 (near HS3ST1, HR 1.89, P = 9.9 × 10-9), and rs335407 (near TFB1M/NOX3, HR 1.25, P = 1.5 × 10-8). Among 204 known CAD loci, 5 were associated with incident CVD in T2D (multiple comparison-adjusted P < 0.00024, 0.05/204). A standardized polygenic score of these 204 variants was associated with incident CVD with HR 1.14 (P = 1.0 × 10-16). CONCLUSIONS The data point to novel and known genomic regions associated with incident CVD among individuals with T2D.",
author = "{on behalf of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium} and Kwak, {Soo Heon} and Hernandez-Cancela, {Ryan B.} and Dicorpo, {Daniel A.} and Condon, {David E.} and Jordi Merino and Peitao Wu and Brody, {Jennifer A.} and Jie Yao and Xiuqing Guo and Fariba Ahmadizar and Mariah Meyer and Murat Sincan and Mercader, {Josep M.} and Sujin Lee and Jeffrey Haessler and Vy, {Ha My T.} and Zhaotong Lin and Armstrong, {Nicole D.} and Shaopeng Gu and Tsao, {Noah L.} and Lange, {Leslie A.} and Ningyuan Wang and Wiggins, {Kerri L.} and Stella Trompet and Simin Liu and Loos, {Ruth J.F.} and Renae Judy and Schroeder, {Philip H.} and Hasbani, {Natalie R.} and Bos, {Maxime M.} and Morrison, {Alanna C.} and Jackson, {Rebecca D.} and Reiner, {Alexander P.} and Manson, {Joann E.} and Chaudhary, {Ninad S.} and Carmichael, {Lynn K.} and {Ida Chen}, {Yii Der} and Taylor, {Kent D.} and Mohsen Ghanbari and {van Meurs}, Joyce and Pitsillides, {Achilleas N.} and Psaty, {Bruce M.} and Raymond Noordam and Ron Do and Park, {Kyong Soo} and {Wouter Jukema}, J. and Maryam Kavousi and Adolfo Correa and Rich, {Stephen S.} and Pankow, {James S.}",
note = "Publisher Copyright: {\textcopyright} 2024 by the American Diabetes Association.",
year = "2024",
month = jun,
doi = "10.2337/dc23-2274",
language = "English (US)",
volume = "47",
pages = "1042--1047",
journal = "Diabetes care",
issn = "0149-5992",
publisher = "American Diabetes Association Inc.",
number = "6",
}