Abstract
OBJECTIVE: In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time-restricted eating (TRE) with an unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.
METHODS: Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m 2 ) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n = 11: 8-hour window, unrestricted eating within window) versus non-TRE (n = 9: unrestricted eating) for 12 weeks. Weight, body composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous glucose monitoring, and 2-week physical activity (actigraphy assessed) were measured during the pre- and end-intervention periods.
RESULTS: The TRE group significantly reduced the eating window (end-intervention window: 9.9 [2.0] hours) compared with the non-TRE group (end-intervention window: 15.1 [1.1] hours) (P < 0.01). Compared with non-TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all P ≤ 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (-21.9% [30.1%]) and reduced weight (-3.7% [1.8%]), fat mass (-4% [2.9%]), lean mass (-3.0% [2.7%]), and visceral fat (-11.1% [13.4%]) (all P ≤ 0.05). Physical activity and metabolic measures remained unchanged.
CONCLUSIONS: In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.
Original language | English (US) |
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Pages (from-to) | 860-869 |
Number of pages | 10 |
Journal | Obesity |
Volume | 28 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2020 |
Bibliographical note
Funding Information:This work was supported by the Healthy Foods Healthy Lives program (17SFR‐2YR50LC to LSC) and the National Institutes of Health (National Center for Advancing Translational Sciences; UL1TR002494).
Publisher Copyright:
© 2020 The Obesity Society.
Keywords
- Adolescent
- Adult
- Aged
- Body Composition/physiology
- Feasibility Studies
- Female
- Humans
- Male
- Middle Aged
- Obesity/therapy
- Overweight/therapy
- Young Adult
PubMed: MeSH publication types
- Research Support, Non-U.S. Gov't
- Journal Article
- Research Support, N.I.H., Extramural