Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study

Lisa S. Chow; Emily N.C. Manoogian; Alison Alvear; Jason G. Fleischer; Honoree Thor; Katrina Dietsche; Qi Wang; James S. Hodges; Nicholas Esch; Samar Malaeb; Tasma Harindhanavudhi; K. Sreekumaran Nair; Satchidananda Panda; Douglas G. Mashek

doi:10.1002/oby.22756

Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study

Lisa S. Chow, Emily N.C. Manoogian, Alison Alvear, Jason G. Fleischer, Honoree Thor, Katrina Dietsche, Qi Wang, James S. Hodges, Nicholas Esch, Samar Malaeb, Tasma Harindhanavudhi, K. Sreekumaran Nair, Satchidananda Panda, Douglas G. Mashek

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

OBJECTIVE: In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time-restricted eating (TRE) with an unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.

METHODS: Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m 2 ) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n = 11: 8-hour window, unrestricted eating within window) versus non-TRE (n = 9: unrestricted eating) for 12 weeks. Weight, body composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous glucose monitoring, and 2-week physical activity (actigraphy assessed) were measured during the pre- and end-intervention periods.

RESULTS: The TRE group significantly reduced the eating window (end-intervention window: 9.9 [2.0] hours) compared with the non-TRE group (end-intervention window: 15.1 [1.1] hours) (P < 0.01). Compared with non-TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all P ≤ 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (-21.9% [30.1%]) and reduced weight (-3.7% [1.8%]), fat mass (-4% [2.9%]), lean mass (-3.0% [2.7%]), and visceral fat (-11.1% [13.4%]) (all P ≤ 0.05). Physical activity and metabolic measures remained unchanged.

CONCLUSIONS: In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.

Original language	English (US)
Pages (from-to)	860-869
Number of pages	10
Journal	Obesity
Volume	28
Issue number	5
DOIs	https://doi.org/10.1002/oby.22756
State	Published - May 1 2020

Bibliographical note

Funding Information:
This work was supported by the Healthy Foods Healthy Lives program (17SFR‐2YR50LC to LSC) and the National Institutes of Health (National Center for Advancing Translational Sciences; UL1TR002494).

Publisher Copyright:
© 2020 The Obesity Society.

Keywords

Adolescent
Adult
Aged
Body Composition/physiology
Feasibility Studies
Female
Humans
Male
Middle Aged
Obesity/therapy
Overweight/therapy
Young Adult

PubMed: MeSH publication types

Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/oby.22756

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Chow, L. S., Manoogian, E. N. C., Alvear, A., Fleischer, J. G., Thor, H., Dietsche, K., Wang, Q., Hodges, J. S., Esch, N., Malaeb, S., Harindhanavudhi, T., Nair, K. S., Panda, S., & Mashek, D. G. (2020). Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study. Obesity, 28(5), 860-869. https://doi.org/10.1002/oby.22756

Chow, LS, Manoogian, ENC, Alvear, A, Fleischer, JG, Thor, H, Dietsche, K, Wang, Q , Hodges, JS, Esch, N, Malaeb, S , Harindhanavudhi, T, Nair, KS, Panda, S & Mashek, DG 2020, 'Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study', Obesity, vol. 28, no. 5, pp. 860-869. https://doi.org/10.1002/oby.22756

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title = "Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study",

abstract = "OBJECTIVE: In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time-restricted eating (TRE) with an unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.METHODS: Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m 2 ) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n = 11: 8-hour window, unrestricted eating within window) versus non-TRE (n = 9: unrestricted eating) for 12 weeks. Weight, body composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous glucose monitoring, and 2-week physical activity (actigraphy assessed) were measured during the pre- and end-intervention periods. RESULTS: The TRE group significantly reduced the eating window (end-intervention window: 9.9 [2.0] hours) compared with the non-TRE group (end-intervention window: 15.1 [1.1] hours) (P < 0.01). Compared with non-TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all P ≤ 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (-21.9% [30.1%]) and reduced weight (-3.7% [1.8%]), fat mass (-4% [2.9%]), lean mass (-3.0% [2.7%]), and visceral fat (-11.1% [13.4%]) (all P ≤ 0.05). Physical activity and metabolic measures remained unchanged.CONCLUSIONS: In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.",

keywords = "Adolescent, Adult, Aged, Body Composition/physiology, Feasibility Studies, Female, Humans, Male, Middle Aged, Obesity/therapy, Overweight/therapy, Young Adult",

author = "Chow, {Lisa S.} and Manoogian, {Emily N.C.} and Alison Alvear and Fleischer, {Jason G.} and Honoree Thor and Katrina Dietsche and Qi Wang and Hodges, {James S.} and Nicholas Esch and Samar Malaeb and Tasma Harindhanavudhi and Nair, {K. Sreekumaran} and Satchidananda Panda and Mashek, {Douglas G.}",

note = "Funding Information: This work was supported by the Healthy Foods Healthy Lives program (17SFR‐2YR50LC to LSC) and the National Institutes of Health (National Center for Advancing Translational Sciences; UL1TR002494). Publisher Copyright: {\textcopyright} 2020 The Obesity Society.",

year = "2020",

month = may,

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doi = "10.1002/oby.22756",

language = "English (US)",

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T1 - Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight

T2 - A Feasibility Study

AU - Chow, Lisa S.

AU - Manoogian, Emily N.C.

AU - Alvear, Alison

AU - Fleischer, Jason G.

AU - Thor, Honoree

AU - Dietsche, Katrina

AU - Wang, Qi

AU - Hodges, James S.

AU - Esch, Nicholas

AU - Malaeb, Samar

AU - Harindhanavudhi, Tasma

AU - Nair, K. Sreekumaran

AU - Panda, Satchidananda

AU - Mashek, Douglas G.

N1 - Funding Information: This work was supported by the Healthy Foods Healthy Lives program (17SFR‐2YR50LC to LSC) and the National Institutes of Health (National Center for Advancing Translational Sciences; UL1TR002494). Publisher Copyright: © 2020 The Obesity Society.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - OBJECTIVE: In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time-restricted eating (TRE) with an unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.METHODS: Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m 2 ) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n = 11: 8-hour window, unrestricted eating within window) versus non-TRE (n = 9: unrestricted eating) for 12 weeks. Weight, body composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous glucose monitoring, and 2-week physical activity (actigraphy assessed) were measured during the pre- and end-intervention periods. RESULTS: The TRE group significantly reduced the eating window (end-intervention window: 9.9 [2.0] hours) compared with the non-TRE group (end-intervention window: 15.1 [1.1] hours) (P < 0.01). Compared with non-TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all P ≤ 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (-21.9% [30.1%]) and reduced weight (-3.7% [1.8%]), fat mass (-4% [2.9%]), lean mass (-3.0% [2.7%]), and visceral fat (-11.1% [13.4%]) (all P ≤ 0.05). Physical activity and metabolic measures remained unchanged.CONCLUSIONS: In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.

AB - OBJECTIVE: In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time-restricted eating (TRE) with an unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.METHODS: Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m 2 ) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n = 11: 8-hour window, unrestricted eating within window) versus non-TRE (n = 9: unrestricted eating) for 12 weeks. Weight, body composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous glucose monitoring, and 2-week physical activity (actigraphy assessed) were measured during the pre- and end-intervention periods. RESULTS: The TRE group significantly reduced the eating window (end-intervention window: 9.9 [2.0] hours) compared with the non-TRE group (end-intervention window: 15.1 [1.1] hours) (P < 0.01). Compared with non-TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all P ≤ 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (-21.9% [30.1%]) and reduced weight (-3.7% [1.8%]), fat mass (-4% [2.9%]), lean mass (-3.0% [2.7%]), and visceral fat (-11.1% [13.4%]) (all P ≤ 0.05). Physical activity and metabolic measures remained unchanged.CONCLUSIONS: In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.

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KW - Aged

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KW - Feasibility Studies

KW - Female

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KW - Male

KW - Middle Aged

KW - Obesity/therapy

KW - Overweight/therapy

KW - Young Adult

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Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

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