Tightening Red-Cell Membranes

Harry S Jacob

Research output: Contribution to journalEditorial

2 Citations (Scopus)

Abstract

The lipid bilayer model of membrane structure proposed by Davson and Danielli1remains an attractive, but imperfect, description of erythrocyte membrane conformation. Important modifications have become necessary in this model, which depicts: (a) hydrophobic lipid components (acyl chains of fatty acids and cholesterol) facing toward the middle of the membrane; (b) hydrophilic components (phosphate, carboxyl, and amino groups of phospholipids) oriented outward toward the cytoplasmic and extracellular surfaces; and (c) proteins layered over both outer and inner surfaces, attached to the hydrophilic portions of the lipid bilayer by ionic bonds. It is clear that the Davson-Danielli structure, although possibly present.

Original languageEnglish (US)
Pages (from-to)1234-1235
Number of pages2
JournalNew England Journal of Medicine
Volume294
Issue number22
DOIs
StatePublished - May 27 1976

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Lipid Bilayers
Cell Membrane
Membranes
Erythrocyte Membrane
Phospholipids
Fatty Acids
Phosphates
Cholesterol
Lipids
Proteins

Cite this

Tightening Red-Cell Membranes. / Jacob, Harry S.

In: New England Journal of Medicine, Vol. 294, No. 22, 27.05.1976, p. 1234-1235.

Research output: Contribution to journalEditorial

Jacob, Harry S. / Tightening Red-Cell Membranes. In: New England Journal of Medicine. 1976 ; Vol. 294, No. 22. pp. 1234-1235.
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