Tightening Red-Cell Membranes

Harry S. Jacob

Research output: Contribution to journalEditorialpeer-review

3 Scopus citations


The lipid bilayer model of membrane structure proposed by Davson and Danielli1remains an attractive, but imperfect, description of erythrocyte membrane conformation. Important modifications have become necessary in this model, which depicts: (a) hydrophobic lipid components (acyl chains of fatty acids and cholesterol) facing toward the middle of the membrane; (b) hydrophilic components (phosphate, carboxyl, and amino groups of phospholipids) oriented outward toward the cytoplasmic and extracellular surfaces; and (c) proteins layered over both outer and inner surfaces, attached to the hydrophilic portions of the lipid bilayer by ionic bonds. It is clear that the Davson-Danielli structure, although possibly present.

Original languageEnglish (US)
Pages (from-to)1234-1235
Number of pages2
JournalNew England Journal of Medicine
Issue number22
StatePublished - May 27 1976


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