TY - JOUR
T1 - Ti-Catalyzed Multicomponent Oxidative Carboamination of Alkynes with Alkenes and Diazenes
AU - Davis-Gilbert, Zachary W.
AU - Yao, Letitia J.
AU - Tonks, Ian A.
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/11/9
Y1 - 2016/11/9
N2 - The inter- or intramolecular oxidative carboamination of alkynes catalyzed by [py2TiCl2NPh]2 is reported. These multicomponent reactions couple alkenes, alkynes and diazenes to form either α,β-unsaturated imines or α-(iminomethyl)cyclopropanes via a TiII/TiIV redox cycle. Each of these products is formed from a common azatitanacyclohexene intermediate that undergoes either β-H elimination or α,γ-coupling, wherein the selectivity is under substrate control.
AB - The inter- or intramolecular oxidative carboamination of alkynes catalyzed by [py2TiCl2NPh]2 is reported. These multicomponent reactions couple alkenes, alkynes and diazenes to form either α,β-unsaturated imines or α-(iminomethyl)cyclopropanes via a TiII/TiIV redox cycle. Each of these products is formed from a common azatitanacyclohexene intermediate that undergoes either β-H elimination or α,γ-coupling, wherein the selectivity is under substrate control.
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U2 - 10.1021/jacs.6b09939
DO - 10.1021/jacs.6b09939
M3 - Article
C2 - 27790910
AN - SCOPUS:84994493720
SN - 0002-7863
VL - 138
SP - 14570
EP - 14573
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 44
ER -