Thyrotropin releasing hormone antagonizes β endorphin hypothermia and catalepsy

John W. Holaday, Liang Fu Tseng, Horace H. Loh, Hao Li Choh Hao Li

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Injection of 30 μg β endorphin intraventricularly (ivt) in rats produced an alteration of body temperature, a state of catalepsy, and an increase in antinociceptive latencies. Subsequent ivt injections of 20 μg of thyrotropin releasing hormone (TRH) reversed the ongoing changes in body temperature and catalepsy produced by β endorphin. Since TRH antagonized these effects in hypophysectomized rats, it is implied that these effects of TRH are independent of pituitary-thyroid involvement. In contrast to the above, TRH did not alter the antinociception produced by β endorphin in either sham-control or hypophysectomized rats. The failure of TRH to antagonize all three of these opiate effects, as well as the inability of TRH to displace bound dihydromorphine from synaptic plasma membranes, suggests that the level of TRH-β endorphin interaction is not at the opiate receptor.

Original languageEnglish (US)
Pages (from-to)1537-1543
Number of pages7
JournalLife Sciences
Volume22
Issue number17
DOIs
StatePublished - May 1 1978

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