Thyrotropin releasing hormone antagonizes β endorphin hypothermia and catalepsy

John W. Holaday, Liang Fu Tseng, Horace H. Loh, Hao Li Choh Hao Li

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


Injection of 30 μg β endorphin intraventricularly (ivt) in rats produced an alteration of body temperature, a state of catalepsy, and an increase in antinociceptive latencies. Subsequent ivt injections of 20 μg of thyrotropin releasing hormone (TRH) reversed the ongoing changes in body temperature and catalepsy produced by β endorphin. Since TRH antagonized these effects in hypophysectomized rats, it is implied that these effects of TRH are independent of pituitary-thyroid involvement. In contrast to the above, TRH did not alter the antinociception produced by β endorphin in either sham-control or hypophysectomized rats. The failure of TRH to antagonize all three of these opiate effects, as well as the inability of TRH to displace bound dihydromorphine from synaptic plasma membranes, suggests that the level of TRH-β endorphin interaction is not at the opiate receptor.

Original languageEnglish (US)
Pages (from-to)1537-1543
Number of pages7
JournalLife Sciences
Issue number17
StatePublished - May 1 1978

Bibliographical note

Funding Information:
We thaak Mr . J .D . Nelson, Ms . Barbara Hitzemann, and Ma . Judy Quinn for assistance . This work was supported in part by the Division of Neuropeychia-try, Walter Reed Army Institute of Research, NIDÂ Grant DA-00565 and NIH Grant MH-30245 . H .H .L . i s a recipient of as NII~i Career Development Award, R2-DA-70554 .


Dive into the research topics of 'Thyrotropin releasing hormone antagonizes β endorphin hypothermia and catalepsy'. Together they form a unique fingerprint.

Cite this