TY - JOUR
T1 - Thymic emigration
T2 - When and how T cells leave home
AU - Weinreich, Michael A.
AU - Hogquist, Kristin A
PY - 2008/8/15
Y1 - 2008/8/15
N2 - The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 α/β T cells, γ/δ T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus and must leave it to provide their functions elsewhere in the body. This article will review recent research indicating differences in the time and migration patterns of T cell subsets found in the thymus. Additionally, we review current understanding of the molecules involved in thymocyte emigration, including the sphingolipid receptor S1P1 and its regulation by the Krüppel-like transcription factor KLF2.
AB - The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 α/β T cells, γ/δ T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus and must leave it to provide their functions elsewhere in the body. This article will review recent research indicating differences in the time and migration patterns of T cell subsets found in the thymus. Additionally, we review current understanding of the molecules involved in thymocyte emigration, including the sphingolipid receptor S1P1 and its regulation by the Krüppel-like transcription factor KLF2.
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U2 - 10.4049/jimmunol.181.4.2265
DO - 10.4049/jimmunol.181.4.2265
M3 - Short survey
C2 - 18684914
AN - SCOPUS:53149130236
SN - 0022-1767
VL - 181
SP - 2265
EP - 2270
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -