Thymic emigration: Sphingosine-1-phosphate receptor-1-dependent models and beyond

Michael B. Drennan, Dirk Elewaut, Kristin A. Hogquist

Research output: Contribution to journalShort survey

10 Scopus citations

Abstract

The thymus is a primary lymphoid organ supporting the development of self-tolerant T cells. Key events in T-cell development in the thymus include lineage commitment, selection events, and thymic emigration. This review discusses the proposed role of sphingosine-1-phosphate and its receptors in the emigration of both conventional and unconventional T-cell subsets from the thymus, and the molecular machinery currently understood to regulate this process. Furthermore, we highlight a role for chemokines and actin-associated proteins in T-cell motility as recent data suggest that T-cell emigration is regulated by more than just a sphingosine-1-phosphate receptor-1-dependent chemotactic axis.

Original languageEnglish (US)
Pages (from-to)925-930
Number of pages6
JournalEuropean Journal of Immunology
Volume39
Issue number4
DOIs
StatePublished - 2009

Keywords

  • Emigration
  • Lymphocyte
  • Thymus

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