Abstract
Thrombotic thrombocytopenic purpura is a relatively uncommon clinical syndrome characterized by thrombocytopenia, hemolytic anemia, and neurologic abnormalities. The case presented followed an infection with rubeola. The patient had a complete remission for 6 months. She manifested unusual skin lesions of the face which could have resulted from thromboses of the cutaneous vessels. Cr51 studies revealed a marked extracorpuscular type of hemolytic process as well as a moderate intracorpuscular hemolytic effect. The role that the phospholipid content of destroyed red cells and platelets have in causing the intravascular clotting in thrombotic thrombocytopenic purpura is discussed. Because of these suggestions further studies delineating changes in serum and/or plasma thromboplastic activity should be undertaken in this syndrome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 823-829 |
| Number of pages | 7 |
| Journal | The Journal of pediatrics |
| Volume | 60 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1962 |
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Thrombotic thrombocytopenic purpura. Report of an unusual clinical case and chromium51 red cell survival studies. / Swaiman, Kenneth F; Schaffhausen, Mildred; Krivit, William.
In: The Journal of pediatrics, Vol. 60, No. 6, 01.01.1962, p. 823-829.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Thrombotic thrombocytopenic purpura. Report of an unusual clinical case and chromium51 red cell survival studies
AU - Swaiman, Kenneth F
AU - Schaffhausen, Mildred
AU - Krivit, William
PY - 1962/1/1
Y1 - 1962/1/1
N2 - Thrombotic thrombocytopenic purpura is a relatively uncommon clinical syndrome characterized by thrombocytopenia, hemolytic anemia, and neurologic abnormalities. The case presented followed an infection with rubeola. The patient had a complete remission for 6 months. She manifested unusual skin lesions of the face which could have resulted from thromboses of the cutaneous vessels. Cr51 studies revealed a marked extracorpuscular type of hemolytic process as well as a moderate intracorpuscular hemolytic effect. The role that the phospholipid content of destroyed red cells and platelets have in causing the intravascular clotting in thrombotic thrombocytopenic purpura is discussed. Because of these suggestions further studies delineating changes in serum and/or plasma thromboplastic activity should be undertaken in this syndrome.
AB - Thrombotic thrombocytopenic purpura is a relatively uncommon clinical syndrome characterized by thrombocytopenia, hemolytic anemia, and neurologic abnormalities. The case presented followed an infection with rubeola. The patient had a complete remission for 6 months. She manifested unusual skin lesions of the face which could have resulted from thromboses of the cutaneous vessels. Cr51 studies revealed a marked extracorpuscular type of hemolytic process as well as a moderate intracorpuscular hemolytic effect. The role that the phospholipid content of destroyed red cells and platelets have in causing the intravascular clotting in thrombotic thrombocytopenic purpura is discussed. Because of these suggestions further studies delineating changes in serum and/or plasma thromboplastic activity should be undertaken in this syndrome.
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U2 - 10.1016/S0022-3476(62)80167-X
DO - 10.1016/S0022-3476(62)80167-X
M3 - Article
VL - 60
SP - 823
EP - 829
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 6
ER -