Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia

A. A. Ashrani, Mark T Reding, Edward W Greeno, A. Shet, N. S. Key

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Porcine factor VIII (pFVIII), which is used to control bleeding in patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII, is not known to increase the risk of arterial or venous thrombosis. We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII. To our knowledge, this is the first such reported thrombotic event. We speculate that platelet activation induced by pFVIII may have contributed to thrombosis and suggest that pFVIII be used with caution in elderly patients with pre-existing cardiovascular risk factors.

Original languageEnglish (US)
Pages (from-to)56-58
Number of pages3
JournalHaemophilia
Volume8
Issue number1
DOIs
StatePublished - 2002

Keywords

  • Cerebrovascular accident
  • Haemophilia A
  • Inhibitor
  • Porcine factor VIII
  • Thrombosis
  • Thrombotic stroke with the use of porcine FVIII

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