Thromboembolic Complications in the First Year after Acute Pancreatitis Diagnosis

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6 Scopus citations


OBJECTIVES: This study aimed to quantify the prevalence of venous thromboembolic (VTE) events in patients with pancreatitis requiring hospitalization and its impact on outcomes.

METHODS: Adult patients admitted from 2011 to 2018 for pancreatitis were identified. Every admission for pancreatitis in the first year after diagnosis was evaluated for a VTE (pulmonary embolism, deep vein thrombosis, or mesenteric vessel thrombosis) within 30 days of discharge. Characteristics of patients who developed a thromboembolic event were compared with those who did not.

RESULTS: There were 4613 patients with pancreatitis identified, 301 of whom developed a VTE (6.5%). Patients who developed a VTE were more likely to be male (P < 0.01), older (P = 0.03), and have an underlying coagulopathy (P < 0.01). Those with VTEs were more likely to die (27% vs 13%, P < 0.01), have more readmissions for pancreatitis (1.7 vs 1.3, P < 0.01), longer length of stay (16 vs 5.5 days, P < 0.01), and be discharged to acute or long-term rehabilitation rather than home (P < 0.01).

CONCLUSIONS: Acute pancreatitis requiring hospitalization is associated with high risk of VTE in the first year after diagnosis. Thromboembolic disease is associated with worse morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)751-755
Number of pages5
Issue number5
StatePublished - 2021

Bibliographical note

Funding Information:
From the Departments of *Surgery, and †Pediatrics, University of Minnesota School of Medicine; and ‡Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN. Received for publication July 3, 2020; accepted April 9, 2021. Address correspondence to: Gregory J. Beilman, MD, Division of Critical Care and Acute Care Surgery, Department of Surgery, University of Minnesota, MMC 195, 420 Delaware St SE, Minneapolis, MN 55455 (e‐mail: This research was supported by the National Institutes of Health's National Center for Advancing Translational Sciences, grant UL1TR002494*. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health's National Center for Advancing Translational Sciences. Research by G.J.B. and A.J.R. are funded by DOD (W81XWH18106872). The authors declare no conflict of interest. Supplemental digital contents are available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal’s Web site ( Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001827

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.


  • mortality
  • pancreatitis
  • thromboembolic events


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