Three new alkaloids from the leaves of Uncaria rhynchophylla

Bin Ma, Chun Fu Wu, Jing Yu Yang, Rui Wang, Yoshihiro Kano, Dan Yuan

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Three new alkaloids, 2′-O-β-d-glucopyranosyl-11-hydroxyvincoside lactam (1), 22-O-demethyl-22-O-β-d-glucopyranosylisocorynoxeine (2), and (4S)-corynoxeine N-oxide (3) were isolated from the leaves of Uncaria rhynchophylla, together with four known tetracyclic oxindole or indole alkaloids, isocorynoxeine N-oxide (4), rhynchophylline N-oxide (5), isorhynchophylline N-oxide (6), and dihydrocorynantheine (7), and an indole alkaloid glycoside, strictosidine (8). The structures of 1 - 3 were elucidated by spectroscopic methods including UV, IR, ESI-TOF-MS, 1D- and 2D-NMR, as well as CD experiments. The activity assay showed that 8 (IC50=8.3 mm) exhibited potent inhibitory activity on lipopolysaccharide(LPS)-induced nitrogen monoxide (NO) release in N9 microglia cells. However, only weak inhibitory activities were observed for 1 - 7 (IC50>100 μm for 1 - 6 or >30 mm for 7).

Original languageEnglish (US)
Pages (from-to)1575-1585
Number of pages11
JournalHelvetica Chimica Acta
Issue number8
StatePublished - Aug 2009


Dive into the research topics of 'Three new alkaloids from the leaves of Uncaria rhynchophylla'. Together they form a unique fingerprint.

Cite this