Three-dimensional myocardial activation imaging in a rabbit model

Chenguang Liu, Xin Zhang, Zhongming Liu, Steven M. Pogwizd, Bin He

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6 Scopus citations


This study evaluated a recently developed three-dimensional (3-D) electrocardiographic imaging (3DECI) approach in a closed-chest rabbit model. First, the performance and sensitivity of parameters of 3DECI were evaluated using a geometrically realistic rabbit heart-torso model. Second, a 3-D intracardiac mapping procedure was evaluated based on the heart-torso rabbit model. Third, comparisons were made among the forward-simulated ventricular activation sequence, the activation sequence derived by the intracardiac mapping, and the 3DECI inverse solution. Finally, the present procedures were tested in vivo in a rabbit, in which the relative error between the measured and imaged activation sequence was 0.20 and the localization error was 5.1 mm. The present simulation and experimental results suggest the merits of the 3DECI imaging approach, and the validity of intracardiac mapping as a tool to evaluate the 3DECI.

Original languageEnglish (US)
Article number1673623
Pages (from-to)1813-1820
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Issue number9
StatePublished - Sep 2006

Bibliographical note

Funding Information:
Manuscript received August 15, 2005; revised December 22, 2005. This work was supported in part by the National Science Foundation under Grant BES-0411480, in part by the American Heart Association under Grant 0140132N, in part by the National Institutes of Health under Grant RO1 EB00178, Grant RO1 HL46929, and Grant RO1 HL73966, and in part by the Biomedical Engineering Institute of the University of Minnesota. The work of C. Liu and Z. Liu was also supported in part by Predoctoral Fellowship from the American Heart Association, Great Midwest Affiliates. Asterisk indicates corresponding author.


  • Body surface mapping
  • Cardiac inverse problem
  • Cardiac mapping
  • Electrocardiographic imaging
  • Intracardiac mapping


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